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Chronic Migraine, Headache: clinical trials and information

Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.
1
Trials with Canadian sites
0
Recruiting in Canada
35
Registry records worldwide

Chronic Migraine, Headache clinical trials in Canada

1 trial, recruiting first
PhaseProvinces
Chronic Migraines and Neurofdeeback Mindfulness
NCT06342219
Unknown statusNot applicableSaskatchewanUniversity of Saskatchewan2024-12

Chronic Migraine, Headache clinical trials worldwide (outside Canada)

34 trials, 9 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Comprehensive Approach to Lifestyle Modification in Chronic Migraine
NCT07802860
Not yet recruitingNot applicableTurkey (Türkiye)Hacettepe University2026-09
EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) OF PRIMARY MOTOR CORTEX ON HEADACHE FREQUENCY IN PATIENTS WITH CHRONIC MIGRAINE
NCT07743814
Not yet recruitingPhase 3IndiaDr. Ram Manohar Lohia Hospital2026-08-01
Comparison Between Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine
NCT07512219
Not yet recruitingNot applicableSohag University2026-05-01
Ultrasound Guided Infratemporal Sphenopalatine Ganglion Supravoltage Versus Standard Voltage Pulsed Radiofrequency for Pain Alleviation in Chronic Refractory Migraine.
NCT07500558
RecruitingNot applicableEgyptMinia University2026-03-31
Occipital Nerve Stimulation in Chronic Migraine
NCT07087678
Not yet recruitingNot applicableUniversity College, London2025-09-01
New Methods for Evaluating Preventive Migraine Treatment
NCT07071506
RecruitingNot applicableDenmarkUniversity of Aarhus2025-06-19
Efficacy of Nerve Block Versus Botox in Chronic Migraine Management
NCT06684249
RecruitingNot applicableEgyptZagazig University2024-11-10
Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine
NCT07159750
RecruitingArgentina, Chile, Colombia, Croatia and 9 moreHospital Universitari Vall d'Hebron Research Institute2024-01-02
Molecular Phenotyping of Migraine Patients According to Sex and Age Through CGRP Quantification
NCT06674772
RecruitingSpainHospital Universitari Vall d'Hebron Research Institute2022-11-29
Open Label, 6-month Study for High Frequency and Chronic Migraine,
NCT06133491
Unknown statusUnited StatesKi Health Partners. LLC2023-10-18
The Efficacy Of Lidocaine Infusion IN Chronic Unilateral Migraine Headache
NCT06109389
Unknown statusPhase 2EgyptAlexandria University2023-10-01
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
NCT06138171
CompletedItalyUniversity of Roma La Sapienza2023-10-01
Pulse Radiofrequency and Occipital Nerve Block for Chronic Migraine Patients
NCT06247592
Unknown statusNot applicableTurkey (Türkiye)Aydin Adnan Menderes University2023-09-26
Study Using the ShiraTronics Migraine Therapy System
NCT05700318
Unknown statusNot applicableAustraliaShiraTronics2023-05-05
COACT Study: CGRPmAbs + OnabotulinumtoxinA Assessment of Chronic Migraine Treatments Study
NCT05724771
Unknown statusPhase 4United StatesChicago Headache Center & Research Institute2023-01-26
A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine
NCT05679908
CompletedPhase 2United StatesTonix Pharmaceuticals, Inc.2022-12-06
Cannabidiol 133mg + Cannabigerol 66mg + Tetrahydrocannabinol 4mg Vs Placebo As Adjuvant Treatment in Chronic Migraine -
NCT04989413
TerminatedPhase 2, Phase 3BrazilHospital Israelita Albert Einstein2022-10-18
Osteopathic Manipulative Techniques for the Treatment of Chronic Migraine Headaches
NCT04520425
TerminatedNot applicableUnited StatesMilton S. Hershey Medical Center2022-09-08
Effect of Auricular Vagus Nerve Stimulation in Women With Migraine Disease
NCT05748535
CompletedNot applicableTurkey (Türkiye)Bahçeşehir University2022-06-06
The Effect of Accompanying Temporomandibular Joint Dysfunction in Patients With Chronic Migraine
NCT05381129
CompletedNot applicableTurkey (Türkiye)Istanbul University - Cerrahpasa2022-05-10
Developing a Mobile Health Pain-Coping Skills Training Program for the Treatment of Chronic Migraine: AIM 4
NCT03465826
WithdrawnNot applicableWake Forest University Health Sciences2022-05-01
Fibromyalgia Syndrome on Patients With Chronic Migraine
NCT05381012
CompletedNot applicableTurkey (Türkiye)Istanbul University - Cerrahpasa2022-05-01
KETOMIGRAINE: Ketogenic Diet in Drug-resistant Chronic Migraineurs
NCT05313503
Unknown statusNot applicableItalyIRCCS National Neurological Institute "C. Mondino" Foundation2022-01-14
Rate , Predictors and Outcome of Chronic Migraine
NCT05079659
Unknown statusEgyptAssiut University2021-01-01
Adjunctive Treatment of Chronic Migraine Using an Oral Dental Device
NCT04871581
CompletedNot applicableUnited StatesChairsideSplint.com2019-10-01
Occipital Blocks for Acute Migraine
NCT03526874
CompletedPhase 3United StatesChildren's Hospital of Philadelphia2019-04-03
Comparison of the Efficacy of Ultrasound-guided Greater Occipital Nerve Block and Pulsed Radiofrequency Therapy in Chronic Migraine Patients
NCT05464212
CompletedNot applicableTurkey (Türkiye)Eskisehir Osmangazi University2019-04-01
Peripheral Nerve Block and Topiramate in the Treatment of Medication Overuse Headaches
NCT03767062
CompletedNot applicableTurkey (Türkiye)Ataturk University2019-03-01
Onabotulinumtoxin Type A Reconstitution With Preserved Versus Preservative-free Saline in Chronic Migraine.
NCT03698409
CompletedPhase 4United StatesState University of New York - Upstate Medical University2019-01-01
Mesotherapy in the Treatment of Chronic Migraine
NCT06118190
CompletedNot applicableTurkey (Türkiye)Kanuni Sultan Suleyman Training and Research Hospital2019-01-01
The Use of Autologous Mesenchymal Stem Cell Preparation for Treatment of Refractory Migraine
NCT04064879
SuspendedNot applicableUnited StatesNeurological Associates of West Los Angeles2018-08-16
A Study Investigating the Efficacy of GON Blocks.
NCT04017741
CompletedPhase 4United KingdomBarts & The London NHS Trust2018-02-14
Onabotulinum Dose Comparison in Chronic Migraine Superior to 100 Units?
NCT04349176
TerminatedPhase 3United StatesUnited States Naval Medical Center, San Diego2017-05-12
A Retrospective Study to Evaluate the Effectiveness of onabotulinumtoxinA in Preventing Headaches in Patients With Chronic Migraines
NCT01749423
WithdrawnAllergan2012-11

About Chronic Migraine, Headache

What is Chronic Migraine, Headache?

Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.

How is Chronic Migraine, Headache usually assessed?

Diagnosis is usually based on the pattern of symptoms described in a history and a neurological examination. A headache diary is often used. Tests may be done to rule out other causes.

What kinds of treatments are studied for Chronic Migraine, Headache?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Chronic Migraine, Headache clinical trials in Canada?

This page lists 1 registry record for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.