Pilot Study of Varenicline to Treat Opioid Dependence
CompletedPhase 1NCT01436474
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The objective of this proposal is to explore the potential of varenicline as a pharmacotherapeutic agent for opioid dependence and addiction.
Study details
- Official title
- The Role of Varenicline in Treating Opioid Dependence: A Pilot Study
- Conditions
- Interventions
- Drug: Varenicline
- Drug: Placebo
- Sponsor
- Mayo Clinic
- Start date
- 2011-06
- Primary completion
- 2012-09
- Sex
- All
- Age range
- from 21 Years
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion criteria * Age\>=21 years * Use of opioids at admission to PRC, with daily morphine equivalent dose\>=60mg * Be able and willing to participate fully in all aspects of the study including one month follow-up after completion of PRC * Ability to provide informed consent Exclusion criteria * Currently using varenicline or other pharmacotherapy for nicotine dependence * Currently pregnant, lactating, or likely to become pregnant during the trial and not willing to use an acceptable form of contraception; * History of a major cardiovascular event in the past 6 months including unstable angina, acute myocardial infarction, stroke, or coronary angioplasty; * Known varenicline allergy * Use of any medication (e.g., methadone, Suboxone) as maintenance therapy for opiate addiction * Identification of illicit drugs (e.g., marijuana, cocaine) on the baseline urine toxicology screen
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01436474