Opioid Dependence: clinical trials and information
Opioid Dependence clinical trials in Canada
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication NCT05585229 | Recruiting | Phase 2 | British Columbia | University of British Columbia | 2025-10-27 |
| Reducing Opioid Use for Chronic Pain Patients Following Surgery NCT03675386 | Recruiting | Not applicable | Ontario | University Health Network, Toronto | 2018-10-15 |
Opioid Dependence clinical trials worldwide (outside Canada)
14 trials, 1 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Better Options for Chronic Cancer Pain NCT06574009 | Recruiting | Phase 4 | United States | VA Office of Research and Development | 2025-10-07 |
| The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients NCT05896878 | Terminated | Not applicable | United States | Hudson Medical | 2023-07-10 |
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis NCT05603702 | Active, not recruiting | Phase 1 | United States | Indiana University | 2023-03-17 |
| Feasibility and Preliminary Efficacy of an Opioid Stewardship Program in Hospitalized Patients With Chronic Pain NCT05370326 | Completed | Not applicable | United States | Yale University | 2022-07-07 |
| Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption NCT03534102 | Withdrawn | Phase 4 | United States | Brigham and Women's Hospital | 2022-06-06 |
| HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis NCT04571619 | Completed | Phase 2 | United States | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 2021-01-03 |
| Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure NCT05463367 | Active, not recruiting | Phase 2 | United States | Northwestern University | 2021-01-01 |
| Collaborative Care for Opioid Dependence And Pain Pilot Study NCT04121546 | Terminated | Not applicable | United States | Indiana University | 2020-09-18 |
| Evaluation of Pain Neuroscience Education for Patients Who Experience Chronic Pain With Concurrent Opioid Dependence NCT06442306 | Completed | Not applicable | United States | Wichita State University | 2020-01-03 |
| Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery NCT04220489 | Terminated | Phase 2 | United States | Jacques E. Chelly | 2019-12-17 |
| Gabapentin Regimens and Their Effects on Opioid Consumption NCT03334903 | Completed | Phase 4 | United States | Brigham and Women's Hospital | 2018-05-15 |
| Developing rTMS Treatment Strategies for Pain in Opiate Dependence NCT03576781 | Completed | Early phase 1 | United States | Medical University of South Carolina | 2017-02-09 |
| Buprenorphine Treatment: A Safe Alternative for Opioid Dependent Pain Patients NCT01841931 | Terminated | Phase 4 | United States | Theresa Jacob, PhD, MPH | 2013-02 |
| Pilot Study of Varenicline to Treat Opioid Dependence NCT01436474 | Completed | Phase 1 | United States | Mayo Clinic | 2011-06 |
About Opioid Dependence
What is Opioid Dependence?
"Opioid Dependence" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 16 chronic pain registry records worldwide.
How is Opioid Dependence usually assessed?
Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.
What kinds of treatments are studied for Opioid Dependence?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Opioid Dependence clinical trials in Canada?
This page lists 2 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related conditions
Related interventions
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.