The Effect of Choice of Intraoperative Opioid on Postoperative Pain
CompletedPhase 4NCT01542645
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The primary aim of this randomized, double-blind study is to examine the effect of a single intraoperative dose of methadone on postoperative pain and analgesic requirements in patients undergoing cardiac surgery with cardiopulmonary bypass. These patients will be compared to subjects receiving a standard dose of the "traditional" intraoperative opioid (fentanyl). Secondary outcome measures to be assessed will include standard recovery variables (such as length of postoperative intubation, ICU length of stay, incidence of nausea or vomiting, level of sedation). In addition, patients will be assessed for the development of chronic postoperative pain.
Study details
- Official title
- The Effect of Choice of Intraoperative Opioid on Postoperative Pain
- Conditions
- Interventions
- Sponsor
- Endeavor Health
- Start date
- 2010-09
- Primary completion
- 2013-11
- Sex
- All
- Age range
- from 18 Years to 90 Years
- Results posted
- Yes, on ClinicalTrials.gov
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * All patients presenting for elective cardiac surgery with CPB will be eligible for enrollment. Exclusion Criteria: 1. Preoperative renal failure requiring dialysis 2. Significant hepatic dysfunction (liver function tests \> 2 times upper normal limit) 3. Preoperative ejection fraction \< 30% 4. Pulmonary disease necessitating home oxygen therapy 5. Preoperative requirement for inotropic agents or intraaortic balloon pump to maintain hemodynamic stability 6. Allergy to methadone or fentanyl 7. Preoperative pain, use of preoperative opioids, or recent history of opioid abuse
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01542645