fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study
Unknown statusNCT03126279
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Painful osteoarthritis (OA) is the 4th largest cause of disability in the UK. Preoperative temporal summation, a measure of central pain facilitation, has been shown to predict postoperative pain after total knee replacement surgery (TKR). The assessment of the brain's response to noxious stimuli using non-invasive functional MRI (fMRI) may be key in identifying imaging biomarkers within the brain that map central sensitization changes seen in OA. fMRI may help explain why up to 20% of patients undergoing TKR surgery develop persistent post-operative pain. To test these concepts the study aims to functionally characterise the brain activity related to temporal summation of pain in healthy individuals and OA patients using a novel fMRI cuff algometer. Assessment of outcomes in terms of pain and function will be performed 6 months post TKR surgery
Study details
- Official title
- Predicting Chronic Post TKR Pain by Assessing Central Sensitisation Using Functional Brain MRI
- Interventions
- Procedure: Total Knee Replacement Surgery
- Sponsor
- University of Nottingham
- Collaborators
- Aalborg University; Medical Research Council; Arthritis Research UK; Royal College of Surgeons of Edinburgh
- Start date
- 2015-08
- Primary completion
- 2017-06
- Sex
- All
- Age range
- from 40 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United Kingdom
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * OA Group Unilateral Knee OA No previous knee surgery Able to give informed consent Age \> 40 years \- Healthy Volunteers Group No OA or knee pain Able to give informed consent Age \> 40 years Exclusion Criteria: -OA Group Major medical, psychiatric, neurological Cx Other chronic pain condition (fibromyalgia) Contraindications to MRI Active Cancer Neuropathic drug treatment -Healthy Volunteers Group Pregnancy Lower limb pain or previous knee surgery Contraindications to MRI Active Cancer Major medical, psychiatric, neurological condition
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03126279