Presence of Signs of Central Sensitization in Episodic and Chronic Migraine
CompletedNot applicableNCT05162664
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Nowadays migraine is conceptualized as a continuum, with at the one hand episodic migraine (EM) and at the other hand chronic migraine (CM) (1). The general aim of the study is to determine where exactly in this continuum central sensitization (CS) appears. Recent studies support the presence of CS in migraine patients (2,3), but controversial evidence exists about where in the continuum exactly CS appears. Some studies determined no differences in sings of CS between EM and CM (4,5), whether other research indicate a clear difference between EM and CM (6-8). However a significant difference in CS parameters could be determined between a patient group (EM or CM) and a healthy control group (3,4,8). In addition, CS appears to be present during the migraine attack (2). In this research, the presence of signs of CS will be determined in between headache phases. The primary outcome measure is identification of CS by PPT, QST, TS, CPM and CSI. Secondary outcome measures are the outcome of the MIDAS, HADS and EUROLIGHT.
Study details
- Official title
- Presence of Signs of Central Sensitization in Episodic and Chronic Migraine - a Cross Sectional Study
- Conditions
- Interventions
- Other: Pressure pain thresholds
- Other: Thermal detection and pain thresholds
- Other: Temporal summation
- Other: Conditioned pain modulation
- Sponsor
- University Ghent
- Start date
- 2021-10-15
- Primary completion
- 2022-08-01
- Sex
- All
- Age range
- from 18 Years to 65 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Belgium
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
The patients should meet the following inclusion criteria: 1. diagnosis of migraine headache based on the criteria of ICDH-3 and verified by a medical doctor, 2. not being pregnant or have given birth in the preceding year, 3. adults between the age of 18 years and 65 years. Exclusion criteria are: 1. any other diagnosis of headache or mixed form, 2. any structural neurological syndrome, 3) any neurological brain event in the past, 4\) surgery at the head, neck or shoulder the last 3 years.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05162664