Effectiveness of Multimodal Physical Therapy in Migraine
Unknown statusNot applicableNCT05226559
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
INTRODUCTION: It is very common that migraine patients could refer neck pain during or after the pain phase of migraine, suggesting that migraine pathophysiological mechanisms could be effective in activating neck pain pathways and be part of the migraine attack. Due to the therapeutic effect of multimodal physical therapy (mobilization and/or manipulation plus exercises) on several pain conditions arising from articular and/or muscular structures such as neck pain, and given the close clinical, anatomical and pathogenetic bi-directional relationship between neck pain and migraine, it would be of interest to evaluate the effectiveness of the physical treatment of the neck region in migraine pain. PURPOSE: to evaluate the efficacy of a combined multimodal physical therapy approach plus usual care vs. usual care alone in subjects with episodic and chronic migraine with concomitant cervical musculoskeletal dysfunctions. STUDY DESIGN: this is a prospective, parallel group, randomized clinical trial. METHODS: A total of 56 subjects aged 18-65 who meet criteria for episodic or chronic migraine with concomitant cervical musculoskeletal dysfunctions will be randomly assigned to receive, musculoskeletal focused multimodal physical therapy (16 sessions over 8 weeks) plus usual care treatment vs. usual care alone. CONFLICT OF INTEREST: not declared.
Study details
- Official title
- Effectiveness of Multimodal Physical Therapy for Episodic and Chronic Migraine With Concomitant Cervical Musculoskeletal Dysfuntions: Randomized Clinical Trial
- Conditions
- Migraine
- Musculoskeletal Neck Pain
- Musculoskeletal Disorder of the Neck
- Chronic Migraine
- Episodic Migraine
- Interventions
- Procedure: Multimodal Physical therapy approach plus usual care
- Drug: Usual care
- Sponsor
- Neuromed IRCCS
- Start date
- 2022-02-24
- Primary completion
- 2024-12
- Sex
- All
- Age range
- from 18 Years to 65 Years
- Results posted
- No results posted in this snapshot
- Countries
- Italy
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion criteria * patients aged 18-65 years; * patients with episodic migraine with and without aura (experiencing 6-14 days/month with migraine); * patients with chronic migraine; * patients who achieved \>30% \<50% reduction from their individual baseline in the number of monthly migraine days on therapy with standard stable pharmacological treatments during the past 3 months; * concomitant cervical dysfunctions. Exclusion criteria * self-report of neck injury/trauma; * acute radiculopathy; * history of carotid or vertebral artery dissection; * stroke; * cervical/cranial nerve block in the past three months; * pregnancy; * history of infection; * migraine attack during the assessment; * diagnosis of other concomitant headaches (such as cervicogenic headache, tension-type headache, cluster headache, medication overuse headache); * having received physical treatment in the past three months or botulinum toxin in the past six months; * any unstable medical o psychiatric condition. * history of any other rheumatic or chronic diseases such as fibromyalgia; * neuralgias, or self-report of vestibular disease.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05226559