Brain MRI for Knee OA
Unknown statusNot applicableNCT05986513
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Brief summary (from the registry)
It has been estimated that 300 million people worldwide have osteoarthritis (OA), and this has increased by 97% over the past 25 years. OA is degenerative joint disease that has joint cartilage break down and causes the surrounding bone to change and rub. The pain and loss of mobility experienced by people with knee OA can seriously reduce quality of life, while pain management causes significant healthcare spending. Unfortunately, the pain associated with OA is complex and difficult to treat other than to have a total knee replacement surgery to replace the damaged bone and surrounding tissues with artificial ones. Our research study plans to use advanced magnetic resonance imaging techniques and novel analysis methods to determine if specific parts of the brain are responsible for difficult to describe and diagnose aspects of chronic pain. This study will help us better understand the effects of chronic pain in the brain and the results will help guide future research into new therapeutic options that would focus on relieving the brain dysfunction caused by chronic pain.
Study details
- Official title
- Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment
- Interventions
- Behavioral: Cold Pressor Gel Test
- Sponsor
- Toronto Rehabilitation Institute
- Collaborators
- McMaster University
- Start date
- 2023-09-01
- Primary completion
- 2025-05-01
- Sex
- All
- Age range
- from 18 Years to 80 Years
- Results posted
- No results posted in this snapshot
- Countries
- Canada
- Total sites listed
- 2
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: 1. Clinical diagnosis and radiographic evidence of knee OA (by rheumatologist). 2. For the two experimental groups (Groups OA-Knee and OA-Knee+Body), participants must have experienced chronic pain related to their knee OA (\>3 months) on most days of each month. 3. Participants in Group OA-Knee+Body must: * Exhibit chronic knee pain and widespread bodily pain at \>3 Michigan Body Map regions. * Meet the Kosek criteria for nociplastic pain: i) the duration/regionality/type of pain, ii) history of hypersensitivities, iii) comorbidity identification, and iv) evoked pain hypersensitivity \[19\] 4. Participants must be able to speak and understand English. Exclusion Criteria: 1. Unable to provide consent (e.g., poor English language skills, etc.) 2. History of liver or kidney disease 3. MRI contraindications: * Pacemaker * Stent * Joint prothesis * Implanted devices * Claustrophobia * Pregnant * Permanent piercings 4. Chronic/abusive use of alcohol and/or illicit drugs 5. Previous clinical diagnosis of fibromyalgia, a multisite pain disorder, a systemic inflammatory disorder (e.g., rheumatoid arthritis, myopathy), depression, post-traumatic stress disorder 6. Previous stroke or moderate/severe traumatic brain injury, subarachnoid hemorrhage, or intracranial hemorrhage 7. Use of psychotropic medications 8. Control subjects (Group OA-PF) also cannot have a history of chronic pain or knee pain caused by osteoporosis or osteoarthritis 9. Total knee replacement 10. Pregnant or chance of being pregnant
Canadian sites (2)
| Facility | City | Province |
|---|---|---|
| Imaging Research Centre, St. Joseph's Healthcare Hamilton | Hamilton | Ontario |
| Toronto Rehabilitation Institute | Toronto | Ontario |
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05986513