Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
RecruitingPhase 2NCT06123715
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
Brief summary (from the registry)
Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.
Study details
- Official title
- PeRiOperative VItamin C to Reduce perSistent paIn After tOtal kNee Arthroplasty (PROVISION): a Pilot Multicentre Randomized Controlled Trial
- Interventions
- Drug: Vitamin C
- Drug: Placebo
- Sponsor
- University Health Network, Toronto
- Collaborators
- Canadian Institutes of Health Research (CIHR); The Arthritis Society, Canada
- Start date
- 2024-04-16
- Primary completion
- 2026-12-31
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- Canada
- Total sites listed
- 3
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Patients \>18 years old * Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee Exclusion Criteria: * TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis * History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency * Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town) * Language difficulties that would impede valid completion of questionnaires * Planned staged bilateral TKA * Treating surgeon deems patient inappropriate for inclusion in trial * Any allergy or sensitivity to milk * Pregnant or planning to become pregnant during the study
Canadian sites (3)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT06123715