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Knee Pain Chronic: clinical trials and information

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.
6
Trials with Canadian sites
2
Recruiting in Canada
122
Registry records worldwide

Knee Pain Chronic clinical trials in Canada

6 trials, recruiting first
PhaseProvinces
Advanced Brain Imaging-TKA (fMRI-TKA)
NCT07464080
RecruitingNot applicableOntarioOttawa Hospital Research Institute2026-04-01
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
NCT06123715
RecruitingPhase 2OntarioUniversity Health Network, Toronto2024-04-16
Intra-Operative Adductor Canal Blocks
NCT05601427
CompletedNot applicableOntarioOttawa Hospital Research Institute2023-03-22
Cryoneurolysis for TKA - a Pilot Study
NCT05286996
Unknown statusNot applicableOntarioUnity Health Toronto2022-12-01
Effect of Buglossoides Oil on Recent Chronic Non-injurious Hip and Knee Pain
NCT03576625
Unknown statusPhase 1New BrunswickRéseau de Santé Vitalité Health Network2018-02-10
Subchondroplasty® Knee RCT
NCT03112200
CompletedNot applicableOntarioZimmer Biomet2017-03-29

Knee Pain Chronic clinical trials worldwide (outside Canada)

116 trials, 17 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success
NCT07494838
Not yet recruitingNot applicableUnited StatesLucas R. Cusumano, MD2026-12-30
A+HA Premium Oral Hyaluronic Acid Drink Functional Evaluation Trial for Delaying Joint Pain
NCT07800676
Not yet recruitingNot applicableTaiwanTaipei Medical University2026-09-01
Stimulation of Peripheral Afferents to Reduce Muscle Inhibition at the Knee
NCT07832669
Not yet recruitingNot applicableNortheastern University2026-09
Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study
NCT07163312
Not yet recruitingChengdu University of Traditional Chinese Medicine2025-10-01
Pain Reprocessing Therapy in Post-Operative Knee Pain
NCT06800209
RecruitingPhase 2United StatesWeill Medical College of Cornell University2025-08-13
Light Therapy on Pain and Synovitis
NCT07057063
RecruitingNot applicableChina, Hong KongThe Hong Kong Polytechnic University2025-07-13
BioPoly® Partial Resurfacing Knee Implant IDE
NCT06915363
RecruitingNot applicableUnited StatesBioPoly LLC2025-03-17
Efficacy of Microparticle Geniculate Artery Embolization in Total Knee Prosthesis Patients With Pain Resistant to Medical Treatment. A Prospective Randomized Controlled Trial
NCT06466330
RecruitingNot applicableFranceSociete Francaise de Rhumatologie2025-03-10
Evaluation Study for the "Jockey Club E-Generation: Impact Extension Project for Chronic Knee Pain Management"
NCT06569836
RecruitingNot applicableHong KongThe University of Hong Kong2024-08-19
Optimizing Pain Self-Management in Total Knee Arthroplasty
NCT06038240
RecruitingNot applicableUnited StatesUniversity of Virginia2023-11-27
RFA or Chemical Neurolysis of the Genicular Nerves Compared to Conservative Treatment for Knee Pain Caused by OA
NCT06094660
RecruitingNot applicableNetherlandsDijklander Ziekenhuis2023-11-27
Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis
NCT06105788
RecruitingNot applicableUnited StatesUniversity of Texas, El Paso2023-11-15
Finding the Optimal Aim of Correction in Opening Wedge High Tibial Osteotomy
NCT06134050
Not yet recruitingNot applicableVestre Viken Hospital Trust2023-11
The Effect of RF Genicular Nerve Block Applied in the Preoperative Period on Fast-track Total Knee Arthroplasty
NCT06239649
RecruitingTurkey (Türkiye)Pamukkale University2023-10-19
Focused Extracorporeal Shockwave Therapy for Knee Arthritis
NCT05596591
RecruitingNot applicableUnited StatesKessler Foundation2022-10-13
SMART Embedded Intervention for Military Postsurgical Engagement Readiness
NCT05050409
RecruitingNot applicableUnited StatesUniversity of Utah2022-05-01
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
NCT04814082
RecruitingNot applicableUnited StatesLifeBridge Health2021-02-01
Investigation of the Effectiveness of Myofascial Release Techniques Applied to the Popliteus Muscle in Individuals With Knee Pain.
NCT07474597
CompletedNot applicableTurkey (Türkiye)Istanbul Rumeli University2025-10-01
Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty
NCT07180953
CompletedPhase 4PolandPoznan University of Medical Sciences2025-09-13
Association Of Knee Pain With High-Impact Workouts Among Gym Participants: A Cross-Sectional Study
NCT07055750
Active, not recruitingPakistanSuperior University2025-03-03
Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain
NCT04472091
WithdrawnNot applicableUnited StatesAndrew Picel2025-01-15
The Acute Effects of Ankle Exercises on Knee Proprioception
NCT07194031
CompletedNot applicableTurkey (Türkiye)Gaziantep Islam Science and Technology University2025-01-06
Two-level ESPB in Total Knee Arthroplasty
NCT06470542
CompletedPhase 4PolandPoznan University of Medical Sciences2024-11-07
Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation.
NCT06581094
CompletedNot applicableTaiwanTaipei Medical University2024-08-20
Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty
NCT06470100
CompletedPhase 4PolandPoznan University of Medical Sciences2024-08-13
Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty
NCT06470204
CompletedPhase 4PolandPoznan University of Medical Sciences2024-08-13
Computer-guided Action Planning to Support Physical Activity (CAPPA) for Employees With Chronic Knee Symptoms
NCT06734052
CompletedNot applicableUnited StatesMarquette University2024-08-12
Evaluation of the Effectiveness of Genicular Block in Postoperative Analgesia in Patients Undergoing Knee Arthroscopy
NCT06413446
Unknown statusBaşakşehir Çam & Sakura City Hospital2024-06-10
Transcranial Direct Current Stimulation in Conjunction With Individualized Physical Therapy for Individuals With Chronic Knee Pain
NCT06132412
Active, not recruitingNot applicableUnited StatesUniversity of Illinois at Chicago2024-06-06
ESPB vs iPACK+ACB in Total Knee Arthroplasty
NCT06302218
Unknown statusPhase 4PolandPoznan University of Medical Sciences2024-04-01
Erector Spinae Plane Block Vs. IPACK Block with Adductor Canal Block for Total Knee Arthroplasty
NCT06233630
CompletedPhase 4PolandPoznan University of Medical Sciences2024-03-30
NLR and PLR Levels Following IPACK Block in Knee Arthroplasty
NCT06304298
CompletedPhase 4PolandPoznan University of Medical Sciences2024-03-30
Effects of IASTM With and Without CT on Pain, ROM, and Functional Disability in Post-Operative Knee Stiffness Patients
NCT06551922
CompletedNot applicablePakistanUniversity of Lahore2024-01-28
Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery
NCT06084403
CompletedNot applicableTurkey (Türkiye)Bursa City Hospital2023-12-20
Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis
NCT05742763
WithdrawnPhase 1, Phase 2United StatesQC Kinetix LLC2023-11-01
Comparison of Concentric-eccentric Exercises in Patellofemoral Pain Syndrome
NCT06197958
Unknown statusNot applicablePakistanRiphah International University2023-10-20
The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis
NCT05999266
CompletedTurkey (Türkiye)Sisli Hamidiye Etfal Training and Research Hospital2023-09-28
Paraffin Wax Bath With Joint Mobilization Technique in Post-traumatic Stiff Knee
NCT06049303
CompletedNot applicablePakistanRiphah International University2023-09-25
Effects of Virtual Reality Rehabilitation and Muscle Energy Technique in Patients With Patellofemoral Pain Syndrome.
NCT05971966
Unknown statusNot applicablePakistanRiphah International University2023-08-30
Cemented vs Cementless Persona Keel RCT
NCT05630053
Active, not recruitingNot applicableUnited StatesZimmer Biomet2023-07-25
Vastus Medialis Activation During McMurray's Test
NCT05965804
Unknown statusEgyptAhram Canadian University2023-07-25
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
NCT05787821
Active, not recruitingUnited StatesZimmer Biomet2023-06-28
A Randomized Controlled Trial for Partial Knee Arthroplasty
NCT05037734
WithdrawnNot applicableUnited StatesZimmer Biomet2023-06
Maximizing Patient Goal Attainment
NCT05652270
Active, not recruitingNot applicableUnited StatesDartmouth-Hitchcock Medical Center2023-05-30
The Effectiveness of Using a Clinical Support Tool in Managing Adolescents With Non-Traumatic Knee Pain
NCT05791513
CompletedNot applicableDenmarkAalborg University2023-05-10
Efficacy of Genicular Nerve Alcohol Neurolysis in Knee Osteoarthritis Pain
NCT06060678
CompletedTurkey (Türkiye)Diskapi Teaching and Research Hospital2023-05-09
Effects of Multi Radiance Medical® Super Pulsed Laser on Chronic Knee Pain
NCT05830344
Unknown statusNot applicableBrazilUniversity of Nove de Julho2023-04-27
HFIT Versus TENS Study for Chronic Low Back and Knee Pain
NCT05821530
Active, not recruitingNot applicableUnited StatesHinge Health, Inc2023-04-24
Prevention, Management and Rehabilitation of Knee Osteoarthritis at the Workplace
NCT05822401
Unknown statusNot applicableNational Research Centre for the Working Environment, Denmark2023-04-11
Quantum Molecular Resonance (QMR) Rehabiltative Treatment of Knee Osteoarthritis
NCT06239805
CompletedNot applicableItalyG. d'Annunzio University2023-02-14

About Knee Pain Chronic

What is Knee Pain Chronic?

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.

How is Knee Pain Chronic usually assessed?

Clinicians usually assess osteoarthritis through a history, physical examination of the joint and, in some cases, X-rays. Blood tests may help rule out other types of arthritis.

What kinds of treatments are studied for Knee Pain Chronic?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Knee Pain Chronic clinical trials in Canada?

This page lists 6 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.