Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty

Brief summary (from the registry)

"The Effect of Dexamethasone Administration Route on Pain and Inflammatory Response in iPACK With ACB for Total Knee Arthroplasty" - written in plain language according to ClinicalTrials.gov standards: The goal of this clinical trial is to learn how the route of dexamethasone administration (either through the vein or nerve block) affects pain and inflammation in people having total knee replacement surgery. All participants will receive two types of nerve blocks before surgery: an iPACK block and an adductor canal block (ACB), which help control pain after the operation. The main questions the study aims to answer are: Does injecting dexamethasone into the nerve block reduce pain more effectively than giving it by vein? Which method leads to a lower inflammatory response after surgery? Researchers will compare the two groups to see which route offers better pain relief and less swelling after knee surgery. Participants will: Be randomly assigned to receive dexamethasone either in the nerve block or by IV Receive standard care for total knee replacement Rate their pain and have blood tests after surgery to measure inflammation

Study details

Official title

Route of Dexamethasone Administration in iPACK and ACB for Total Knee Replacement: A Randomized Trial

Conditions

• Osteoarthritis, Knee
• Knee Pain Chronic
• Arthropathy of Knee

Interventions

• Drug: NaCl 0.9%
• Drug: Dexamethasone 4mg
• Drug: Dexamethasone 4mg

Sponsor

Poznan University of Medical Sciences

Start date

2025-09-13

Primary completion

2026-03-01

Sex

All

Age range

from 65 Years to 100 Years

Results posted

No results posted in this snapshot

Countries

Poland

Total sites listed

1

Eligibility criteria