Lower Back Pain: clinical trials and information
Lower Back Pain clinical trials in Canada
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain NCT00361504 | Completed | Phase 3 | Alberta, British Columbia, Nova Scotia, Ontario, Quebec, Saskatchewan | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 2006-11 |
Lower Back Pain clinical trials worldwide (outside Canada)
27 trials, 5 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Semaglutide for Low Back Pain NCT07731256 | Not yet recruiting | Phase 2 | United States | Washington University School of Medicine | 2027-02-01 |
| Adia Med of Winter Park LLC Lower Back Pain Research Study NCT07587047 | Recruiting | Phase 1 | United States | Adia Med of Winter Park LLC | 2026-06-16 |
| Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain NCT07122453 | Recruiting | Phase 1 | United States | Centrexion Therapeutics | 2026-03 |
| Peripheral Nerve Stimulation With the SPRINT® System in Chronic PSIJC Pain NCT07166952 | Recruiting | Not applicable | United States | Medical University of South Carolina | 2025-10-26 |
| Brain Mechanisms Supporting Cannabis-induced Pain Relief NCT04982965 | Recruiting | Early phase 1 | United States | University of California, San Diego | 2021-05-07 |
| Effects of a Lower Back Wrap Device on Lower Back Pain, Physical Function, and Quality of Life NCT06749912 | Completed | Not applicable | United States | State University of New York at Buffalo | 2024-12-02 |
| Anxiety Level Among Patients With Chronic Low Back Pain NCT06404788 | Completed | Poland | Medical University of Silesia | 2024-11-27 | |
| Measuring Reliability of Spine Mobilization in Low Back Pain NCT07582705 | Completed | United States | University of Kansas Medical Center | 2024-10-02 | |
| What Are Persistent Lower Back Pain Patients' Views of Sleep Health Within an Outpatient Musculoskeletal Physiotherapy Setting? NCT06094517 | Unknown status | Sheffield Hallam University | 2023-12-01 | ||
| Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain NCT06071962 | Unknown status | Phase 3 | Germany | Apurano Pharmaceuticals GmbH | 2023-11-02 |
| Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain NCT06072560 | Unknown status | Phase 3 | Germany | Apurano Pharmaceuticals GmbH | 2023-11-02 |
| Improving Access to Chiropractic Care in Community Health Centers NCT06104605 | Active, not recruiting | Not applicable | United States | Boston Medical Center | 2023-11-01 |
| Post Isometric Relaxation and Core Stability Exercises in Sacroiliac Joint Dysfunction NCT05529602 | Completed | Not applicable | Pakistan | Riphah International University | 2021-12-01 |
| Clinical Efficacy of IoMT-based Exercise Program for the Elderly NCT05197010 | Unknown status | Not applicable | South Korea | Samsung Medical Center | 2021-10-13 |
| Using Music During Lumbar Medial Branch Block Procedure NCT04091607 | Completed | Not applicable | United States | Wake Forest University Health Sciences | 2019-11-15 |
| Burst Spinal Cord Stimulation for Neuropathic Pain. NCT03733886 | Completed | Not applicable | Norway, Sweden | Oslo University Hospital | 2019-09-09 |
| Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent NCT03681769 | Completed | Early phase 1 | United States | Medical University of South Carolina | 2019-02-22 |
| Influence of the Pilates Method in the Treatment of Unexpected Chronic Lombar Pain NCT03854643 | Completed | Not applicable | Brazil | Universidade Cruzeiro do Sul | 2018-04-02 |
| Restorative Exercise for Strength Training and Operational Resilience (RESTORE) for Chronic or Recurrent Low Back Pain NCT02132910 | Completed | Not applicable | United States | Defense and Veterans Center for Integrative Pain Management | 2013-12 |
| Neurosteroids as Novel Therapeutic Agents for Chronic Pain in OEF/OIF Veterans NCT01898013 | Completed | Phase 2 | United States | Durham VA Medical Center | 2013-09-13 |
| Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine NCT02529566 | Unknown status | United States | The Foundation for Spinal Research, Education and Humanitarian Care, Inc. | 2013-07 | |
| Evaluation Of Efficacy And Safety Of Norspan In Moderate To Severe Pain Due To Osteoarthritis, Rheumatoid Arthritis, Joint/Muscle Pain NCT01961271 | Completed | Phase 4 | Hong Kong, Philippines, South Korea | Mundipharma Pte Ltd. | 2013-06 |
| Investigation of Efficacy of Botulinum Toxin A (Dysport) in Chronic Low Back Pain NCT02221648 | Terminated | Phase 2 | United States | Yale University | 2012-12 |
| Naltrexone and Clonidine Combination (ATNC05) in the Treatment of Chronic Back Pain NCT01415895 | Completed | Phase 2 | United States | Annette C. Toledano MD | 2011-07 |
| Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Pain, Responders and Non-Responders? NCT00885859 | Unknown status | Netherlands | Maastricht University Medical Center | 2009-06 | |
| E-STIM Trial: Comparing the Efficacy of the Empi Select TENS to a Control for the Treatment of Chronic Lower Back Pain NCT00709748 | Unknown status | Not applicable | United States | Empi, A DJO Company | 2008-02 |
| Open-Label Extension to Evaluate the Long-Term Safety, Tolerability and Analgesic Efficacy NCT00904280 | Completed | Phase 3 | United States | Endo USA Inc., a Keenova Therapeutics Company | 2001-03 |
About Lower Back Pain
What is Lower Back Pain?
Chronic low back pain is back pain that lasts for 12 weeks or longer. In many cases no single specific cause is found. It is one of the most common reasons people see a health professional.
How is Lower Back Pain usually assessed?
Assessment usually involves a history and physical examination, with attention to warning signs that may need urgent investigation. Imaging is not needed in every case; clinicians decide based on symptoms and findings.
What kinds of treatments are studied for Lower Back Pain?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Lower Back Pain clinical trials in Canada?
This page lists 1 registry record for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related conditions
- Back Pain Lower Back Chronic59 trials
- Chronic Lower Back Pain19 trials
- Lower Back Pain Chronic18 trials
- Low Back Pain632 trials
- Chronic Low Back Pain384 trials
- Chronic Low-back Pain245 trials
- Back Pain145 trials
- Chronic Low Back Pain (CLBP)71 trials
- Chronic Low-back Pain (cLBP)36 trials
- Failed Back Surgery Syndrome32 trials
- Chronic Back Pain28 trials
- Chronic Non-specific Low Back Pain26 trials
Related interventions
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.