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Lower Back Pain: clinical trials and information

Chronic low back pain is back pain that lasts for 12 weeks or longer. In many cases no single specific cause is found. It is one of the most common reasons people see a health professional.
1
Trials with Canadian sites
0
Recruiting in Canada
28
Registry records worldwide

Lower Back Pain clinical trials in Canada

1 trial, recruiting first
PhaseProvinces
A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain
NCT00361504
CompletedPhase 3Alberta, British Columbia, Nova Scotia, Ontario, Quebec, SaskatchewanJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2006-11

Lower Back Pain clinical trials worldwide (outside Canada)

27 trials, 5 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Semaglutide for Low Back Pain
NCT07731256
Not yet recruitingPhase 2United StatesWashington University School of Medicine2027-02-01
Adia Med of Winter Park LLC Lower Back Pain Research Study
NCT07587047
RecruitingPhase 1United StatesAdia Med of Winter Park LLC2026-06-16
Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain
NCT07122453
RecruitingPhase 1United StatesCentrexion Therapeutics2026-03
Peripheral Nerve Stimulation With the SPRINT® System in Chronic PSIJC Pain
NCT07166952
RecruitingNot applicableUnited StatesMedical University of South Carolina2025-10-26
Brain Mechanisms Supporting Cannabis-induced Pain Relief
NCT04982965
RecruitingEarly phase 1United StatesUniversity of California, San Diego2021-05-07
Effects of a Lower Back Wrap Device on Lower Back Pain, Physical Function, and Quality of Life
NCT06749912
CompletedNot applicableUnited StatesState University of New York at Buffalo2024-12-02
Anxiety Level Among Patients With Chronic Low Back Pain
NCT06404788
CompletedPolandMedical University of Silesia2024-11-27
Measuring Reliability of Spine Mobilization in Low Back Pain
NCT07582705
CompletedUnited StatesUniversity of Kansas Medical Center2024-10-02
What Are Persistent Lower Back Pain Patients' Views of Sleep Health Within an Outpatient Musculoskeletal Physiotherapy Setting?
NCT06094517
Unknown statusSheffield Hallam University2023-12-01
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain
NCT06071962
Unknown statusPhase 3GermanyApurano Pharmaceuticals GmbH2023-11-02
Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain
NCT06072560
Unknown statusPhase 3GermanyApurano Pharmaceuticals GmbH2023-11-02
Improving Access to Chiropractic Care in Community Health Centers
NCT06104605
Active, not recruitingNot applicableUnited StatesBoston Medical Center2023-11-01
Post Isometric Relaxation and Core Stability Exercises in Sacroiliac Joint Dysfunction
NCT05529602
CompletedNot applicablePakistanRiphah International University2021-12-01
Clinical Efficacy of IoMT-based Exercise Program for the Elderly
NCT05197010
Unknown statusNot applicableSouth KoreaSamsung Medical Center2021-10-13
Using Music During Lumbar Medial Branch Block Procedure
NCT04091607
CompletedNot applicableUnited StatesWake Forest University Health Sciences2019-11-15
Burst Spinal Cord Stimulation for Neuropathic Pain.
NCT03733886
CompletedNot applicableNorway, SwedenOslo University Hospital2019-09-09
Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
NCT03681769
CompletedEarly phase 1United StatesMedical University of South Carolina2019-02-22
Influence of the Pilates Method in the Treatment of Unexpected Chronic Lombar Pain
NCT03854643
CompletedNot applicableBrazilUniversidade Cruzeiro do Sul2018-04-02
Restorative Exercise for Strength Training and Operational Resilience (RESTORE) for Chronic or Recurrent Low Back Pain
NCT02132910
CompletedNot applicableUnited StatesDefense and Veterans Center for Integrative Pain Management2013-12
Neurosteroids as Novel Therapeutic Agents for Chronic Pain in OEF/OIF Veterans
NCT01898013
CompletedPhase 2United StatesDurham VA Medical Center2013-09-13
Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine
NCT02529566
Unknown statusUnited StatesThe Foundation for Spinal Research, Education and Humanitarian Care, Inc.2013-07
Evaluation Of Efficacy And Safety Of Norspan In Moderate To Severe Pain Due To Osteoarthritis, Rheumatoid Arthritis, Joint/Muscle Pain
NCT01961271
CompletedPhase 4Hong Kong, Philippines, South KoreaMundipharma Pte Ltd.2013-06
Investigation of Efficacy of Botulinum Toxin A (Dysport) in Chronic Low Back Pain
NCT02221648
TerminatedPhase 2United StatesYale University2012-12
Naltrexone and Clonidine Combination (ATNC05) in the Treatment of Chronic Back Pain
NCT01415895
CompletedPhase 2United StatesAnnette C. Toledano MD2011-07
Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Pain, Responders and Non-Responders?
NCT00885859
Unknown statusNetherlandsMaastricht University Medical Center2009-06
E-STIM Trial: Comparing the Efficacy of the Empi Select TENS to a Control for the Treatment of Chronic Lower Back Pain
NCT00709748
Unknown statusNot applicableUnited StatesEmpi, A DJO Company2008-02
Open-Label Extension to Evaluate the Long-Term Safety, Tolerability and Analgesic Efficacy
NCT00904280
CompletedPhase 3United StatesEndo USA Inc., a Keenova Therapeutics Company2001-03

About Lower Back Pain

What is Lower Back Pain?

Chronic low back pain is back pain that lasts for 12 weeks or longer. In many cases no single specific cause is found. It is one of the most common reasons people see a health professional.

How is Lower Back Pain usually assessed?

Assessment usually involves a history and physical examination, with attention to warning signs that may need urgent investigation. Imaging is not needed in every case; clinicians decide based on symptoms and findings.

What kinds of treatments are studied for Lower Back Pain?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Lower Back Pain clinical trials in Canada?

This page lists 1 registry record for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.