Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients
CompletedPhase 4NCT01591382
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Patients who are dependent on opioids often have poor pain relief after major surgery. This study tests the hypothesis that adding intravenous ketamine to a postoperative regimen of intravenous opioids for postoperative pain will improve pain relief in this subset of patients.
Study details
- Official title
- Hydromorphone PCA or Hydromorphone PCA With Ketamine for Acute Postoperative Pain Relief in Opioid-Dependent Chronic Pain Patients
- Conditions
- Interventions
- Drug: Ketamine
- Drug: Placebo
- Drug: Hydromorphone PCA
- Sponsor
- Brigham and Women's Hospital
- Start date
- 2008-09
- Primary completion
- 2011-06
- Sex
- All
- Age range
- from 18 Years
- Results posted
- Yes, on ClinicalTrials.gov
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Chronic pain \> 6 months * Long term use of opioids * Major surgery Exclusion Criteria: * Use of regional anesthetic techniques * No need for intravenous (IV) patient controlled analgesia (PCA) after surgery
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01591382