Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting

CompletedPhase 4NCT03450161

View the official record on ClinicalTrials.gov

Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.

This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.

Brief summary (from the registry)

Randomized, double-blinded, three arm study in adult patients undergoing first time coronary artery bypass grafting (CABG) surgery with median sternotomy. The investigators will examine the effects of three fentanyl dosing schemes (high-dose bolus, low-dose bolus, continuous dose) on the area of hyperalgesia and allodynia at 24 and 48h as well as on persisting pain at 3, 6, and 12 months. Additionally, the investigators will measure fentanyl concentrations throughout anesthesia.

Study details

Official title: Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting
Conditions: Hyperalgesia
Opioid Use
Pain, Postoperative
Pain, Chronic
Interventions: Drug: Fentanyl dosing schemes
Sponsor: University Hospital, Ghent
Collaborators: University Hospital, Basel, Switzerland
Start date: 2018-05-14
Primary completion: 2020-02-01
Sex: All
Age range: from 18 Years
Results posted: No results posted in this snapshot
Countries: Belgium
Total sites listed: 1

Eligibility criteria

Show eligibility criteria (verbatim from the registry)

Inclusion Criteria: * Consenting patients aged ≥18 years * Undergoing first-time, elective, on-pump CABG surgery with median sternotomy and central cannulation. Exclusion Criteria: * Documentation of preexisting chronic pain as per electronic record * Use of opioids in the last 30 days or history/documentation of opioid abuse as per electronic record * BMI \> 35kg/m2 or history of obstructive sleep apnea syndrome * Patients with renal failure (clearance \< 30 ml/min) * Neuraxial anesthesia * Pregnancy * Planned wound infiltration with local anesthetics * Known drug allergies or intolerance to fentanyl or other opioids * Expected to be unable to understand pinprick/allodynia testing / follow-up questions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03450161