Gabapentin Regimens and Their Effects on Opioid Consumption

Brief summary (from the registry)

The purpose of this study is to determine the best strategy of administering gabapentin in connection with our current approach to perioperative pain management. We aim to evaluate two different adjunct gabapentin regimens given in the perioperative period, and to identify which manages patient pain more effectively and safely. In this evaluation, we will identify the quantity of patients' opioid consumption, the quality of their pain management, and the frequency and severity of any side effects they might experience. Patients who are undergoing total knee replacement (TKR) and choose to participate will be randomly assigned to a treatment group using computer-generated randomization. Patients in group 1 (the control group) will receive the standard of care as pertains to gabapentin. This consists of a single 600 mg dose of gabapentin administered to the patient approximately one to two hours before surgery, then a dose of 600 mg each morning during postoperative admission. Patients in Group 2 will receive 600 mg preoperatively, plus an additional postoperative gabapentin regimen: they will take 300 mg of gabapentin every 8 hours for 1 week, then a single nightly dose of 300 mg for another month.

Study details

Official title

Gabapentin Regimens and Their Effects on Opioid Consumption

Conditions

• Knee Osteoarthritis
• Knee Pain Chronic
• Opioid Use
• Opioid Dependence

Interventions

• Drug: Gabapentin

Sponsor

Brigham and Women's Hospital

Start date

2018-05-15

Primary completion

2019-04-24

Sex

All

Age range

from 18 Years

Healthy volunteers

true

Results posted

Yes, on ClinicalTrials.gov

Countries

United States

Total sites listed

1

Eligibility criteria