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Complex Regional Pain Syndromes: clinical trials and information

Complex regional pain syndrome (CRPS) is a chronic pain condition that usually affects an arm or a leg, often after an injury, surgery, stroke or heart attack. The pain is out of proportion to the original injury and may come with changes in skin colour, temperature or swelling.
3
Trials with Canadian sites
0
Recruiting in Canada
33
Registry records worldwide

Complex Regional Pain Syndromes clinical trials in Canada

3 trials, recruiting first
PhaseProvinces
Feasibility Study of Combined Peripheral Nerve Block and Physiotherapy for CRPS
NCT05589259
Unknown statusNot applicableOntarioTracy Cupido2025-02-01
Impact of the Ultrasound-guided Approach on the Efficiency and Safety of the Stellate Ganglion Block in Chronic Pain
NCT01954888
TerminatedNot applicableQuebecMaisonneuve-Rosemont Hospital2013-09
Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS)
NCT00689585
TerminatedPhase 2QuebecMcGill University Health Centre/Research Institute of the McGill University Health Centre2008-09

Complex Regional Pain Syndromes clinical trials worldwide (outside Canada)

30 trials, 4 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Graded Motor Imagery Effects on Body Perception Disturbance in Complex Regional Pain Syndrome : a Randomised Controlled Trial
NCT07818174
Not yet recruitingNot applicableFranceNantes University Hospital2026-10-01
Dance-therapy and Chronic Pain
NCT05689944
RecruitingNot applicableFranceHospices Civils de Lyon2024-03-01
Supraspinal Processing of Sensory Aspects of Pain
NCT05814497
RecruitingNot applicableUnited StatesChildren's Hospital Medical Center, Cincinnati2023-05-01
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
NCT04144972
RecruitingNot applicableUnited StatesUniversity of California, San Francisco2019-10-24
Ketamine and Midazolam Infusions for CRPS: Feasibility Study
NCT05945147
WithdrawnPhase 2United StatesStanford University2099-01-01
The Comparison of Sympathetic Blockade of Stellate Ganglion Block and Thoracic Sympathetic Ganglion Block
NCT06130514
Unknown statusNot applicableSeoul National University2024-07-10
The Success of Lumbar Sympathetic Ganglion Block Using Lower Extremity Perfusion Index
NCT06241820
CompletedNot applicableSouth KoreaJeongsoo Kim2024-02-13
Investigation of the Efficacy of Transcranial Magnetic Stimulation in Patients Developing Complex Regional Pain Syndrome Type 1 in the Upper Extremity During the Subacute-Chronic Period After Ischemic Stroke
NCT06215079
Unknown statusNot applicableTurkey (Türkiye)Ankara City Hospital Bilkent2023-11-15
Empowered Relief for Youth
NCT05998369
CompletedNot applicableUnited StatesStanford University2023-08-09
Low-Intensity Focused Ultrasound For Insular Neuromodulation in Chronic Pain
NCT05751096
Unknown statusNot applicableUnited StatesCarilion Clinic2023-07-15
Assessing the Impact of Exercise Based Intensive Interdisciplinary Pain Treatment (IIPT) on Endogenous Pain Modulation in Youth With Chronic Pain Syndromes
NCT05491499
CompletedUnited StatesBoston Children's Hospital2022-10-17
Intraoperative Neuromonitoring Recording With a Novel SCS Paddle: Phase II
NCT05459324
CompletedNot applicableUnited StatesAlbany Medical College2022-06-08
Transcranial Magnetic Stimulation for Chronic Neuropathic Pain
NCT05593237
Active, not recruitingNot applicableUnited StatesUniversity of California, San Francisco2022-04-25
Sensory Testing of Multiple Forms of Spinal Cord Stimulation for Pain
NCT04732325
CompletedNot applicableUnited StatesUniversity of Michigan2021-09-11
The Comparison of Sympathetic Blockade of Stellate Ganglion Block and Thoracic Paravertebral Block
NCT04876989
CompletedNot applicableSouth KoreaSeoul National University2021-07-21
Evaluation of Online Tool (E-TOOL SCS) in Spinal Cord Stimulaion
NCT06229015
CompletedItalyIstituti Clinici Scientifici Maugeri SpA2021-07-13
Embodied Virtual Reality for Chronic Pain
NCT05160038
CompletedNot applicableSwitzerlandUniversity of Zurich2021-05-31
Virtual Reality Guided Imagery for Chronic Pain
NCT04849897
CompletedNot applicableUnited StatesUniversity of Southern California2021-03-22
The Complex Regional Pain Syndrome (CRPS) is a Chronic Pain Condition. This is a Preliminary Study to Explore and Test Clinical Hypothesis. They Suppose That CRPS Patients Have Impairment in Their Mental or Motor Imagery Abilities.
NCT04703348
CompletedNot applicableFranceCentre Hospitalier Universitaire de Nīmes2021-01-12
Treatment of Complex Regional Pain Syndrome, a Long-term Follow-up
NCT04597866
CompletedSwedenUppsala University2020-09-21
Intraoperative Neuromonitoring Recording With a Novel SCS Paddle
NCT05045625
CompletedNot applicableUnited StatesAlbany Medical College2020-01-10
Neuroimaging Study on the Effect of Transdermal Buprenorphine in Complex Regional Pain Syndrome Patients
NCT03977012
Unknown statusSouth KoreaSeoul National University Hospital2019-06-11
Audio-Visual Relaxation Technology for Pediatric Amplified Musculoskeletal Pain Syndrome
NCT03762213
CompletedNot applicableUnited StatesTufts Medical Center2018-12-20
Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain
NCT04060875
CompletedUnited StatesKaruna Labs Inc.2017-09-21
Quality of Life and Pain Changes Due to DRG Stimulation for Chronic Pain
NCT03417973
TerminatedUnited StatesKM Clinical Research Group2017-08-01
Virtual Environment Rehabilitation for Patients With Motor Neglect Trial
NCT03887962
Unknown statusNot applicableUnited KingdomCambridge University Hospitals NHS Foundation Trust2017-05-01
Novel Treatment Option for Neuropathic Pain
NCT02490436
CompletedPhase 2NorwaySorlandet Hospital HF2015-10
Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study)
NCT00377468
Unknown statusPhase 2GermanyLudwig-Maximilians - University of Munich2006-09
Evoked Fields After Median and Ulnar Stimulation
NCT00217243
CompletedNetherlandsMedical Center Alkmaar2005-06
Study of Proteins Associated With Complex Regional Pain Syndrome
NCT00033969
TerminatedUnited StatesNational Institute of Nursing Research (NINR)2002-04-15

About Complex Regional Pain Syndromes

What is Complex Regional Pain Syndromes?

Complex regional pain syndrome (CRPS) is a chronic pain condition that usually affects an arm or a leg, often after an injury, surgery, stroke or heart attack. The pain is out of proportion to the original injury and may come with changes in skin colour, temperature or swelling.

How is Complex Regional Pain Syndromes usually assessed?

CRPS is diagnosed clinically, based on history and examination using published diagnostic criteria, after other causes have been considered.

What kinds of treatments are studied for Complex Regional Pain Syndromes?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Complex Regional Pain Syndromes clinical trials in Canada?

This page lists 3 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.