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Knee Arthritis: clinical trials and information

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.
1
Trials with Canadian sites
0
Recruiting in Canada
23
Registry records worldwide

Knee Arthritis clinical trials in Canada

1 trial, recruiting first
PhaseProvinces
Intra-Operative Adductor Canal Blocks
NCT05601427
CompletedNot applicableOntarioOttawa Hospital Research Institute2023-03-22

Knee Arthritis clinical trials worldwide (outside Canada)

22 trials, 0 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain
NCT04472091
WithdrawnNot applicableUnited StatesAndrew Picel2025-01-15
Two-level ESPB in Total Knee Arthroplasty
NCT06470542
CompletedPhase 4PolandPoznan University of Medical Sciences2024-11-07
Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty
NCT06470100
CompletedPhase 4PolandPoznan University of Medical Sciences2024-08-13
Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty
NCT06470204
CompletedPhase 4PolandPoznan University of Medical Sciences2024-08-13
ESPB vs iPACK+ACB in Total Knee Arthroplasty
NCT06302218
Unknown statusPhase 4PolandPoznan University of Medical Sciences2024-04-01
Erector Spinae Plane Block Vs. IPACK Block with Adductor Canal Block for Total Knee Arthroplasty
NCT06233630
CompletedPhase 4PolandPoznan University of Medical Sciences2024-03-30
Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function
NCT05886608
CompletedNot applicableItalyContrad Swiss SA2022-08-30
A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis
NCT05975879
CompletedNot applicableRussiaNPO Petrovax2022-05-31
Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain
NCT05103527
Active, not recruitingNot applicableUnited StatesKenneth B Chapman2022-01-01
Lyophilized and Micronized Particulate Human Amniotic and Umbilical Cord (TTAX03) for KL Grade 3-4 Knee OA
NCT05079035
CompletedPhase 2United StatesBioTissue Holdings, Inc2021-12-06
Robotic-assisted Total Knee Arthroplasty vs. Conventional One
NCT04611815
CompletedNot applicablePolandMedical University of Warsaw2020-12-01
ROMTECH PortableConnect Rehabilitation Device Usage Post Unilateral Total Knee Arthroplasty (TKA)
NCT04497129
CompletedNot applicableUnited StatesROM Technologies, INC2020-08-17
Gold Factor on Knee Joint Health and Function
NCT05347602
CompletedNot applicableUnited States4Life Research, LLC2020-08-03
Pain Management After Adductor Canal Block for Total Knee Arthroplasty
NCT06086483
CompletedPhase 4PolandPoznan University of Medical Sciences2020-06-18
Pulsed Radiofrequency and Osteoarthritic Chronic Knee Pain
NCT04454710
CompletedNot applicableItalyUniversity of Rome Tor Vergata2020-01-01
Rate of Torque Development and Voluntary Quadriceps Activation in Patients With Knee Osteoarthritis: A Quantitative Analysis Before and After a Single Session of Manual Physical Therapy
NCT04234282
Unknown statusNot applicableUnited StatesJennifer Moreno Clinic2020-01
Cognition, Pain and Wellbeing
NCT04620525
TerminatedUnited KingdomUniversity of Nottingham2019-11-07
Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients
NCT03980964
CompletedNot applicableUnited StatesCyMedica Orthopedics, Inc2019-06-07
Knee Arthritis Treatment With Autologous Fragmented Adipose Tissue and PRP - Comparison of Two Treatment Methods
NCT04321629
Unknown statusPhase 2PolandRehasport Clinic2018-07-30
Performance of MOTO Medial® Unicompartmental Knee Arthroplasty
NCT03211663
Active, not recruitingUnited StatesMedacta USA2017-10-09
AP-003-C Study to Confirm the Efficacy of Ampion™ in Adults With Pain Due to Severe Osteoarthritis of the Knee
NCT03182686
CompletedPhase 3United StatesAmpio Pharmaceuticals. Inc.2017-06-19
NEUROIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the Knee Joint
NCT02967302
Unknown statusPhase 2, Phase 3GermanyHildrun Haibel2015-08

About Knee Arthritis

What is Knee Arthritis?

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.

How is Knee Arthritis usually assessed?

Clinicians usually assess osteoarthritis through a history, physical examination of the joint and, in some cases, X-rays. Blood tests may help rule out other types of arthritis.

What kinds of treatments are studied for Knee Arthritis?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Knee Arthritis clinical trials in Canada?

This page lists 1 registry record for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.