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Osteoarthritis of the Knee: clinical trials and information

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.
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Trials with Canadian sites
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Recruiting in Canada
10
Registry records worldwide

Osteoarthritis of the Knee clinical trials in Canada

No registry record in this snapshot uses this exact term with a site in Canada. See related conditions below.

Osteoarthritis of the Knee clinical trials worldwide (outside Canada)

10 trials, 0 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis
NCT05742763
WithdrawnPhase 1, Phase 2United StatesQC Kinetix LLC2023-11-01
Extended and Controlled Release Liposomal Formulated Dexamethasone for Chronic Knee OA Pain
NCT04123561
CompletedPhase 3Australia, United StatesTaiwan Liposome Company2019-11-26
A Study to Assess the Analgesic Efficacy of ASP7962 in Patients With Pain Due to Osteoarthritis of the Knee
NCT02611466
CompletedPhase 2Belgium, Czechia, Germany, Hungary and 2 moreAstellas Pharma Europe B.V.2016-02-16
A Study of Duloxetine (LY248686) in Participants With Chronic Osteoarthritis and Knee Pain in Japan
NCT02248480
CompletedPhase 3JapanEli Lilly and Company2014-10
Sleep, Pain and Inflammatory Processes in Older Adults With Osteoarthritis
NCT01683799
CompletedNot applicableUnited StatesUniversity of Rochester2013-02
A Prospective Study Evaluating the Treatment of Knee Osteoarthritis With the Cryo-Touch III Device
NCT01704157
CompletedNot applicableUnited StatesPacira Pharmaceuticals, Inc2012-09
A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain
NCT01619839
CompletedPhase 2United StatesNektar Therapeutics2012-06
Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee
NCT00988091
CompletedPhase 3United StatesFerring Pharmaceuticals2009-09
Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee
NCT00531427
CompletedPhase 3United StatesPurdue Pharma LP2007-09
Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA)
NCT00667654
CompletedPhase 2United StatesCentrexion Therapeutics2007-08

About Osteoarthritis of the Knee

What is Osteoarthritis of the Knee?

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.

How is Osteoarthritis of the Knee usually assessed?

Clinicians usually assess osteoarthritis through a history, physical examination of the joint and, in some cases, X-rays. Blood tests may help rule out other types of arthritis.

What kinds of treatments are studied for Osteoarthritis of the Knee?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Osteoarthritis of the Knee clinical trials in Canada?

No registry record in this snapshot uses this exact term with a site in Canada. Related terms are linked below. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.